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Related Experiment Videos

Nocturia and depression.

R Asplund1, S Henriksson, S Johansson

  • 1Family Medicine Stockholm, Karolinska Institute, Huddinge, Sweden. ragnar.asplund@jll.se

BJU International
|June 8, 2004
PubMed
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Major depression (MD) significantly increases the risk of nocturia in both men and women. This study found MD was linked to a six-fold higher risk in men and a three-fold higher risk in women, independent of age and health.

Area of Science:

  • Urology
  • Psychiatry
  • Sleep Medicine

Background:

  • Nocturia, the frequent need to urinate at night, affects a significant portion of the adult population.
  • The potential link between mental health conditions, specifically major depression (MD), and nocturia requires further investigation.

Purpose of the Study:

  • To investigate the association between major depression and the occurrence of nocturia in an adult population.
  • To quantify the risk of nocturia in individuals with major depression compared to those without.

Main Methods:

  • A postal questionnaire survey was administered to an unselected adult population in Ostersund, Sweden.
  • The Major Depression Inventory (MDI) was used for depression diagnostics, alongside questions on nocturia, general health, and sleep patterns.

Related Experiment Videos

  • Multiple logistic regression analysis was employed to identify independent correlates of nocturia.
  • Main Results:

    • Nocturia (≥2 nocturnal voids) was reported by 15.6% of men and 16.5% of women.
    • Major depression was independently associated with a 6.5-fold increased risk of nocturia in men and a 2.8-fold increased risk in women.
    • Age and self-reported health status were also significant independent correlates for nocturia in both sexes.

    Conclusions:

    • Major depression is a significant risk factor for nocturia in both men and women, even after adjusting for age and health.
    • Potential mechanisms include altered antidiuretic hormone secretion and reduced nocturnal bladder capacity, possibly influenced by serotonergic pathways.
    • These findings highlight the importance of considering mental health in the evaluation and management of nocturia.