Related Experiment Video
Updated: Aug 15, 2026
14:54
Rat Model of Photochemically-Induced Posterior Ischemic Optic Neuropathy
Published on: November 29, 2015
Visual loss despite anticoagulation in radiation-induced optic neuropathy
Clinical & Experimental Ophthalmology
|June 8, 2004
Summary
Brain radiation therapy can cause delayed necrosis and functional loss. This case highlights radiation-induced optic neuropathy developing two years post-treatment, even with anticoagulation, questioning its efficacy for this specific complication.
Area of Science:
- Neurology
- Oncology
- Ophthalmology
Background:
- Radiation therapy for brain tumors can lead to long-term side effects.
- Cerebral radiation necrosis and functional deficits may occur months after treatment.
- Radiation-induced optic neuropathy is a potential complication of cranial radiation.
Observation:
- A 62-year-old male patient developed radiation-induced optic neuropathy.
- The onset occurred two years after treatment for a left temporal lobe glioma.
- The patient was undergoing anticoagulation therapy at the time of neuropathy development.
Findings:
- Anticoagulation is often considered beneficial for cerebral radiation necrosis.
- The effectiveness of anticoagulation in treating radiation-induced optic neuropathy remains uncertain.
- This case suggests anticoagulation may not prevent optic neuropathy post-brain radiation.
Implications:
- Further research is needed to clarify the role of anticoagulation in managing radiation-induced optic neuropathy.
- Clinical practice guidelines may need re-evaluation regarding anticoagulation use in patients receiving cranial radiation.
- Understanding and mitigating delayed radiation effects is crucial for improving patient outcomes after brain tumor treatment.
More Related Videos
Related Concept Videos
01:25Glaucoma: Overview
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
01:27Open Angle Glaucoma: Treatment
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
01:28Angle Closure Glaucoma: Treatment
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
01:22Photoreceptors and Visual Pathways
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...
01:27Diabetic Retinopathy
DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...