Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Fertilization

Fertilization

During fertilization, an egg and sperm cell fuse to create a new diploid structure. In humans, the process occurs once the egg has been released from the ovary, and travels into the fallopian tubes. The process requires several key steps: 1) sperm present in the genital tract must locate the egg; 2) once there, sperm need to release enzymes to help them burrow through the protective zona pellucida of the egg; and 3) the membranes of a single sperm cell and egg must fuse, with the sperm...

Cell Migration

Cell Migration

Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.

Metastasis

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

Types of Signaling Molecules

Types of Signaling Molecules

In multicellular organisms, many molecules transmit signals between cells to pass information. These signals vary in complexity and include small peptides, nucleotides, steroids, fatty acid derivatives, and dissolved gases such as nitric oxide. Some signaling molecules diffuse through the plasma membrane to act locally between neighboring cells or travel long distances. Others remain attached to the cell surface, transmitting information to other cells only when they make contact. In some...

Cell Adhesion Molecules - Types and Functions

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily involved in a...

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Long-Range Transverse-Momentum Correlations and Radial Flow in Pb-Pb Collisions at the LHC.

Physical review letters·2026

Same author

Expert-involved continuous renal replacement therapy device development: addressing user needs through human factors engineering.

Expert review of medical devices·2025

Same author

Multimodal floral cues resembling both generalized food sources and oviposition sites in Isotrema manshuriense (Aristolochiaceae) pollinated by flies.

Plant biology (Stuttgart, Germany)·2025

Same author

Identification of plasma protein biomarkers for endometriosis and the development of statistical models for disease diagnosis.

Human reproduction (Oxford, England)·2024

Same author

Changes in nutritional status and the development of obesity and metabolic syndrome following pediatric heart transplantation.

Pediatric transplantation·2024

Same author

Corrigendum: Introducing a healthcare-assistive robot in primary care: a preliminary questionnaire survey.

Frontiers in robotics and AI·2023

Search research articles

Related Experiment Video

Updated: Jul 5, 2026

Loss- and Gain-of-function Approach to Investigate Early Cell Fate Determinants in Preimplantation Mouse Embryos

Loss- and Gain-of-function Approach to Investigate Early Cell Fate Determinants in Preimplantation Mouse Embryos

Published on: June 6, 2016

Molecular cues to implantation.

S K Dey¹, H Lim, Sanjoy K Das

¹Department of Pediatrics, Vanderbilt University Medical Center, MCN D4100, Nashville, Tennessee 37232, USA. sk.dey@vanderbilt.edu

Endocrine Reviews

|June 8, 2004

Summary

Understanding uterine receptivity and blastocyst competence is key to successful implantation. Research into molecular signals aims to improve pregnancy rates and address implantation failure.

More Related Videos

Single Cell Collection of Trophoblast Cells in Peri-implantation Stage Human Embryos

Single Cell Collection of Trophoblast Cells in Peri-implantation Stage Human Embryos

Published on: June 12, 2020

Establishment of an Embryo Implantation Model In Vitro

Establishment of an Embryo Implantation Model In Vitro

Published on: June 21, 2024

Related Experiment Videos

Last Updated: Jul 5, 2026

Loss- and Gain-of-function Approach to Investigate Early Cell Fate Determinants in Preimplantation Mouse Embryos

Loss- and Gain-of-function Approach to Investigate Early Cell Fate Determinants in Preimplantation Mouse Embryos

Published on: June 6, 2016

Single Cell Collection of Trophoblast Cells in Peri-implantation Stage Human Embryos

Single Cell Collection of Trophoblast Cells in Peri-implantation Stage Human Embryos

Published on: June 12, 2020

Establishment of an Embryo Implantation Model In Vitro

Establishment of an Embryo Implantation Model In Vitro

Published on: June 21, 2024

Area of Science:

Reproductive Biology
Developmental Biology
Genetics

Background:

Successful embryo implantation requires complex reciprocal communication between the blastocyst and the receptive uterus.
Uterine receptivity is a transient state critical for blastocyst acceptance and implantation initiation.
Current understanding of the molecular dialogue governing implantation remains incomplete.

Purpose of the Study:

To explore molecular signals regulating uterine receptivity and blastocyst implantation competence.
To identify novel pathways involved in the implantation process.
To provide insights for improving pregnancy rates and addressing implantation failure.

Main Methods:

Analysis of gene expression data, including microarray experiments.
Utilizing genetically engineered mouse models to study implantation mechanisms.
Investigating key molecular mediators such as growth factors, cytokines, and adhesion molecules.

Main Results:

Gene expression studies and mouse models have identified critical factors in implantation.
Microarray data offers a vast resource for discovering new molecular pathways.
Specific growth factors, cytokines, lipid mediators, adhesion molecules, and transcription factors play roles.

Conclusions:

Further exploration of molecular signals is crucial for a comprehensive understanding of implantation.
Unraveling these signals can lead to therapeutic strategies for reproductive health issues.
Integrating diverse data sources will advance knowledge of complementary and redundant pathways in implantation.