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[Clinical studies on panipenem/betamipron in pediatrics]
T Sekiguchi1, T Okamoto, K Ohara
1Department of Pediatrics, Takamatsu Red Cross Hospital.
Insights
Panipenem/betamipron (PAPM/BP) effectively treated pediatric bacterial infections, including pneumonia and skin infections. The antibiotic showed high clinical response and bacterial eradication rates with minimal side effects in children.
Area of Science:
- Pediatric Infectious Diseases
- Antibiotic Therapy
- Pharmacology
Background:
- Acute bacterial infections pose significant health risks in children.
- Effective and safe antibiotic options are crucial for pediatric care.
- Panipenem/betamipron (PAPM/BP) is an antibiotic combination for bacterial infections.
Observation:
- A study evaluated PAPM/BP in 15 children with acute bacterial infections.
- Infections included acute pneumonia, staphylococcal scalded skin syndrome, and urinary tract infections.
- Treatment involved 30-minute drip infusions of PAPM/BP.
Findings:
- All 15 pediatric patients achieved good to excellent clinical responses.
- Bacterial eradication was confirmed for all 12 identified bacterial strains.
- One patient experienced urticaria; mild GOT/GPT elevations and eosinophilia were noted in separate cases.
Implications:
- PAPM/BP demonstrates significant efficacy in treating diverse pediatric bacterial infections.
- The antibiotic is well-tolerated, with a favorable safety profile in the pediatric population.
- PAPM/BP represents a valuable therapeutic option for pediatric infectious disease management.
Abstract:
Panipenem/betamipron (PAPM/BP) was given by 30 minutes drip infusion to 15 children with acute bacterial infections including 11 with acute pneumonia, 2 each with staphylococcal scalded skin syndrome and urinary tract infections. Good to excellent clinical responses were obtained in all of the 15 patients and bacterial eradications were obtained for all 12 strains identified in these cases. Urticaria considered to be drug related was observed in 1 patient. Slight elevations of GOT and GPT and eosinophilia were observed in 1 case each. From the above clinical results, it appears that PAPM/BP is a useful antibiotic for treatment of pediatric patients with various bacterial infections.