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Near-triploid acute lymphoblastic leukemia with TEL/AML1 translocation
Sameer Bakhshi1, Meera Chitlur, Barbara Cushing
1Division of Pediatric Hematology Oncology, Department of Pediatrics, Children's Hospital of Michigan, Wayne State University and School of Medicine, Detroit, MI 48201, USA. sambakh@hotmail.com
Indian Pediatrics
|June 8, 2004
Abstract:
An 11-year-old girl was diagnosed as B-precursor acute lymphoblastic leukemia (ALL) with co-expression of myeloid antigens. Cytogenetic analysis revealed a near-triploid (75-82 chromosomes/cell) abnormal chromosomal complement. Fluroscent in situ hybridization studies indicated presence of TEL/AMLI fusion genes. We discuss the prognostic relevance of TEL/AML1 in this rare near-triploid subtype of ALL.