Near-triploid acute lymphoblastic leukemia with TEL/AML1 translocation
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Sameer Bakhshi1, Meera Chitlur, Barbara Cushing
1Division of Pediatric Hematology Oncology, Department of Pediatrics, Children's Hospital of Michigan, Wayne State University and School of Medicine, Detroit, MI 48201, USA. sambakh@hotmail.com
An 11-year-old girl was diagnosed as B-precursor acute lymphoblastic leukemia (ALL) with co-expression of myeloid antigens. Cytogenetic analysis revealed a near-triploid (75-82 chromosomes/cell) abnormal chromosomal complement. Fluroscent in situ hybridization studies indicated presence of TEL/AMLI fusion genes. We discuss the prognostic relevance of TEL/AML1 in this rare near-triploid subtype of ALL.
An 11-year-old girl was diagnosed as B-precursor acute lymphoblastic leukemia (ALL) with co-expression of myeloid antigens. Cytogenetic analysis revealed a near-triploid (75-82 chromosomes/cell) abnormal chromosomal complement. Fluroscent in situ hybridization studies indicated presence of TEL/AMLI fusion genes. We discuss the prognostic relevance of TEL/AML1 in this rare near-triploid subtype of ALL.
