Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Immunophenotypic analysis in acute leukemia].

K Akashi1, M Harada

  • 1First Department of Internal Medicine, Faculty of Medicine, Kyushu University.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|June 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Efficacy of pembrolizumab in microsatellite-stable, tumor mutational burden-high metastatic colorectal cancer: genomic signatures and clinical outcomes.

ESMO open·2025
Same author

Comparing the safety and efficacy of nintedanib starting dose in patients with connective tissue disease-associated interstitial lung diseases.

Scandinavian journal of rheumatology·2024
Same author

Favorable clinical response and drug retention of anti-IL-6 receptor inhibitor in rheumatoid arthritis with high CRP levels: the ANSWER cohort study.

Scandinavian journal of rheumatology·2021
Same author

Development of a Langmuir probe array for radial potential profile measurement in the collisional merging formation FRC.

The Review of scientific instruments·2021
Same author

Generation of a novel CD30<sup>+</sup> B cell subset producing GM-CSF and its possible link to the pathogenesis of systemic sclerosis.

Clinical and experimental immunology·2020
Same author

Usefulness of medication instruction sheets for sharing information on cancer chemotherapy within the health care team.

Die Pharmazie·2019
Same journal

[Development of novel therapeutics for multiple myeloma and improvement of drug lag].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Clinical pharmacy services to patients of immunomodulatory drugs].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Therapeutic drug monitoring of the new anti-myeloma drugs in the treatment of multiple myeloma].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Prognostic value of minimal residual disease assessment using next-generation sequencing in multiple myeloma].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[The evaluation of minimal residual disease in multiple myeloma by an allele-specific oligonucleotide real-time PCR].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Evaluation of minimal residual disease in myeloma by multiparametric flow cytometry].

Nihon rinsho. Japanese journal of clinical medicine·2019
See all related articles

Immunophenotyping and gene analysis refine acute leukemia classification beyond FAB criteria. These immunological studies help identify specific leukemia subtypes for improved treatment strategies.

Area of Science:

  • Hematology
  • Immunology
  • Molecular Biology

Context:

  • Traditional French-American-British (FAB) classification relies on morphocytochemical features.
  • Acute leukemias require precise subtyping for effective treatment.
  • Immunophenotyping and gene rearrangement analysis offer advanced diagnostic capabilities.

Purpose:

  • To explore the utility of immunophenotyping and clonal gene rearrangement analysis in classifying acute leukemias.
  • To differentiate between B-lineage and T-lineage acute lymphoblastic leukemia (ALL).
  • To define new entities within acute myelogenous leukemia (AML), such as AML-M0 and CD7-positive AML.

Summary:

  • Immunophenotyping and gene analysis provide a more precise staging of hematopoietic differentiation in leukemia blasts.

Related Experiment Videos

  • B-lineage ALL and T-lineage ALL are classified by antigen expression.
  • AML-M0 requires specific markers (myeloperoxidase, CD13, CD33) for diagnosis, and CD7-positive AML is identified as an immature subtype.

    • Impact:

    • Immunological studies enable the discrimination of specific leukemia subgroups.
    • This improved classification may lead to more targeted and effective treatment approaches for acute leukemias.
    • Advances in leukemia diagnostics contribute to better patient outcomes.