Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The hyperimmunoglobulin E syndrome.

Chen-Tong Hsu1, Yu-Tsan Lin, Yao-Hsu Yang

  • 1Department of Pediatrics, Yung Ho Branch, Cardinal Tien Hospital, Taipei, Taiwan, ROC.

Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi
|June 8, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Response to "Comment on 'The characteristics and risk factors of cerebrovascular events in young systemic lupus erythematosus patients: A case-control study".

Journal of the Formosan Medical Association = Taiwan yi zhi·2026
Same author

Novel CD8<sup>+</sup> Regulatory T Cells Attenuate Eosinophilic Infiltration in a Murine Allergic Asthma Model.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2026
Same author

Prognostic Factors for Sideroblastic Anemia with B-cell Immunodeficiency, Periodic Fevers, and Developmental Delay Due to TRNT1 Gene Mutations: A Case Report and Systematic Review.

Journal of clinical immunology·2026
Same author

Low IgE and absence of sensitization in non-T2 asthma: a transcriptomic and cytokine study.

Frontiers in immunology·2026
Same author

The Biological and Prognostic Implications of the Nicotinic Acetylcholine Receptor α3, α5, and α7 Subunits in Oral Squamous Cell Carcinoma.

Cancer medicine·2025
Same author

ZNF334 truncation mutation drives cold-induced autoinflammation.

EMBO molecular medicine·2025
Same journal

A fungal-induced immune response that mediates resistance against COVID-19.

Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi·2026
Same journal

Foreign body infection following Staphylococcus aureus bloodstream infection: Host risk factors and bacterial genetic characteristics.

Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi·2026
Same journal

MicroRNAs in sepsis diagnosis: A systematic review and meta-analysis toward evidence-based biomarker development.

Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi·2026
Same journal

Outcomes associated with carbapenem-sparing versus carbapenem-containing therapy for third-generation cephalosporin non-susceptible Serratia marcescens bacteremia: a retrospective cohort analysis.

Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi·2026
Same journal

Corrigendum to "Younger adults with mild-to-moderate COVID-19 exhibited more prevalent olfactory dysfunction in Taiwan" [J Microbiol Immunol Infect 54 (2021) 794-800].

Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi·2026
Same journal

Combined Aspergillus-specific IgG and galactomannan testing optimizes diagnosis of invasive pulmonary aspergillosis in non-neutropenic patients.

Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi·2026
See all related articles

Hyperimmunoglobulin E syndrome, a primary immunodeficiency, presents with high IgE levels and recurrent infections. This case highlights diagnostic challenges and key laboratory findings in a young boy.

Area of Science:

  • Immunology
  • Genetics
  • Dermatology

Background:

  • Hyperimmunoglobulin E syndrome (HIES) is a primary immunodeficiency characterized by elevated serum IgE, eczema, recurrent infections, and immune dysregulation.
  • Diagnosis is challenging due to variable presentation, often mimicking severe atopy or other immunodeficiencies, with no definitive clinical diagnostic tools.
  • Laboratory investigations are crucial for definitive diagnosis, involving assessment of IgE levels, neutrophil function, and T cell responses.

Observation:

  • A 6-year-old boy presented with recurrent methicillin-resistant Staphylococcus aureus (MRSA) furunculosis.
  • Physical examination revealed characteristic features including pruritic dermatitis and furunculosis on the scalp, neck, and back.
  • The patient exhibited a peculiar facial appearance.

Findings:

Related Experiment Videos

  • Laboratory results showed mild leukocytosis with eosinophilia and markedly elevated serum IgE levels.
  • Defective neutrophil chemotaxis was observed.
  • Impaired lymphocyte proliferation in response to anti-CD3/CD28 monoclonal antibodies indicated T cell dysfunction.

Implications:

  • This case underscores the importance of comprehensive laboratory evaluation for diagnosing Hyperimmunoglobulin E syndrome, especially in children with recurrent severe infections and atopic features.
  • Early and accurate diagnosis is essential for appropriate management and to prevent long-term complications associated with HIES.
  • Further research into the genetic basis and improved diagnostic markers for HIES is warranted to aid clinicians in differentiating it from other conditions.