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[Immune gene rearrangement as markers of hematological malignancies]

N Morita¹, K Ohishi, K Kita

¹Second Department of Internal Medicine, School of Medicine, Mie University.

Nihon Rinsho. Japanese Journal of Clinical Medicine

|June 1, 1992

Abstract:

Molecular genetical analysis using Ig and TCR genes has been applied for hematological malignancies. In acute leukemias, this method is used to clarify the cellular lineage, and in malignant lymphomas to detect the monoclonal component. In this article, we describe the mechanism of immune gene rearrangement and the present status and future directions of immunogenetic analysis of leukemias and lymphomas.

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