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Decrease of the platelet 5-HT2A receptor function by long-term imipramine treatment in endogenous depression.

Esther Gómez-Gil1, Cristóbal Gastó, Marta Carretero

  • 1Instituto Clínic de Psiquiatría y Psicología, Hospital Clinic, Villarroel, Barcelona, Spain. esgomez@clinic.ub.es

Human Psychopharmacology
|June 8, 2004
PubMed
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Long-term antidepressant treatment with imipramine significantly decreased serotonin-amplified platelet aggregation in patients with major depressive disorder. This suggests that changes in serotonin 2A (5-HT2A) receptor function may be linked to antidepressant efficacy.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Psychiatry

Background:

  • Animal studies suggest antidepressants decrease serotonin 2A (5-HT2A) receptor density and function.
  • Human studies on antidepressant effects on 5-HT2A receptors remain inconclusive.
  • Serotonin-amplified platelet aggregation serves as a physiological marker for 5-HT2A receptor activity.

Purpose of the Study:

  • To investigate if long-term antidepressant treatment alters 5-HT2A receptor functioning in patients with endogenous depression.
  • To assess changes in serotonin-amplified platelet aggregation as an indicator of 5-HT2A receptor status.

Main Methods:

  • Studied serotonin-amplified platelet aggregation to adenosine diphosphate (ADP) in 15 untreated major depressive disorder patients.
  • Measured platelet aggregation as an indirect assessment of platelet 5-HT2A receptor function.

Related Experiment Videos

  • Repeated measurements after symptom remission induced by imipramine treatment (150-300 mg/day), with 15 controls.

    • Main Results:

    • A statistically significant decrease in serotonin-amplified platelet aggregation to ADP was observed post-treatment (p = 0.038).
    • The reduction occurred after an average of 145 +/- 27 days of imipramine treatment.

    Conclusions:

    • Effective imipramine treatment led to reduced platelet 5-HT2A receptor-mediated function.
    • This desensitization or down-regulation of 5-HT2A receptor function may contribute to antidepressant therapeutic effects.
    • Platelet aggregometry shows potential as a surrogate measure for antidepressant action in intra-subject studies.