Related Experiment Video
Updated: Aug 24, 2026

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
Published on: February 28, 2019
[Renal cell carcinoma metastases to nose and paranasal sinuses presenting as recurrent epistaxis]
Marcin Szymański1, Anna Szymańska, Kamal Morshed
1Katedry i Kliniki Otolaryngologii i Onkologii Laryngologicznej, Akademii Medycznej w Lublinie.
Abstract:
Distant metastases in head and neck region are very uncommon. Nasal bleeding was the first symptom in a patient with metastasis from renal cell carcinoma. Nasal tumour biopsy revealed renal carcinoma to be the primary lesion. Initially the patient refused surgery and nephrectomy was performed 8 months later. MR scans demonstrated diffuse intracranial invasion which made complete removal impossible. Potential routes of renal carcinoma spread are presented. Renal cell carcinoma should be considered in the diagnosis of nose and paranasal tumours. Epistaxis can be the first symptom of renal carcinoma metastasis to the nose and paranasal sinuses.
Related Concept Videos
Epistaxis
Etiology
Possible causes of this condition include high blood pressure, trauma, low humidity, upper respiratory tract infections, allergies, foreign bodies, nasal inhalation of corticosteroids or illicit drugs, excessive use of decongestant nasal sprays, facial or nasal surgery, anatomic malformation, tumors, or systemic...
Nose and Nasal Cavity