Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Bleeding time].

H Takami1, Y Tamai, K Kariya

  • 1First Department of Internal Medicine, Hirosaki University School of Medicine.

Rinsho Byori. the Japanese Journal of Clinical Pathology
|March 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The impact of neoadjuvant therapy in patients with left-sided resectable pancreatic cancer: an international multicenter study.

Annals of oncology : official journal of the European Society for Medical Oncology·2025
Same author

Association of symptomatic gallstones and primary hyperparathyroidism: a propensity score-matched analysis.

The British journal of surgery·2021
Same author

Phase I/II study of adding intraperitoneal paclitaxel in patients with pancreatic cancer and peritoneal metastasis.

The British journal of surgery·2020
Same author

Development of Albumin Analyzer with Whole Blood and Application to Telemedicine for Patient Nutrition Management in Home Health Nursing.

Studies in health technology and informatics·2019
Same author

Detection Algorithm for Inadequate Blood Specimens Due to Contamination with an Infusion Solution in the Clinical Chemistry Tests: Prevention of Incidents by Blood Draw Error.

Studies in health technology and informatics·2019
Same author

Intratumoural immune cell landscape in germinoma reveals multipotent lineages and exhibits prognostic significance.

Neuropathology and applied neurobiology·2019

Monoclonal antibodies targeting von Willebrand Factor (vWF) and GPIb significantly prolonged bleeding time, impacting primary hemostasis. Anti-GPIIb/IIIa antibodies inhibited platelet aggregation but had minimal effect on bleeding time.

Area of Science:

  • Hematology
  • Immunology
  • Physiology

Context:

  • Bleeding time assesses platelet-vessel wall interactions and primary hemostasis.
  • Current bleeding time tests have limitations in sensitivity, specificity, and reproducibility.
  • Monoclonal antibodies offer targeted approaches to study hemostasis.

Purpose:

  • To investigate the inhibitory effects of anti-vWF, anti-GPIb, and anti-GPIIb/IIIa monoclonal antibodies on primary hemostasis.
  • To evaluate the impact of these antibodies on bleeding time and hemostatic plug formation in vivo.
  • To assess the utility of quantitative bleeding time in diagnosing bleeding disorders.

Summary:

  • Infusion of anti-vWF and anti-GPIb antibodies in pigs markedly prolonged bleeding time and disrupted hemostatic plug formation.

Related Experiment Videos

  • Anti-GPIIb/IIIa antibodies effectively inhibited ADP- and collagen-induced platelet aggregation but caused only minor bleeding time prolongation.
  • Quantitative bleeding time, measuring duration and blood loss, aids in diagnosing hemorrhagic disorders and treatment efficacy.

    • Impact:

    • Provides insights into the mechanisms of primary hemostasis.
    • Highlights the distinct roles of vWF, GPIb, and GPIIb/IIIa in hemostasis.
    • Suggests potential therapeutic targets for bleeding disorders.