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Promoter Capture Hi-C: High-resolution, Genome-wide Profiling of Promoter Interactions
Published on: June 28, 2018
[Specific promoter activity of CIITA-pI in dendritic cells]
1Department of Laboratory Diagnosis, Changhai Hospital, The Second Military Medical University, Shanghai 200433, China.
Abstract
Aim:
To detect whether CIITA-pI can drive reporter gene expression and its specific promoter activity in DCs.
Methods:
Luciferase reporter system was used to detect 112 bp CIITA-pI specific promoter activity in DCs.
Results:
CIITA-pI could drive expression of reporter gene in DCs but not in HEK 293 cells and its promoter activity increased with the maturation of DCs.
Conclusion:
Our work provides a basis for further study of targeting DC gene therapy using CIITA-pI as DC-specific promoter.
