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Published on: October 30, 2013
[Immunological up-regulation of cyclophosphamide-treated mice by turtle blood extract]
Ying Wang1, Hui-zhen Zhang, Shu-jun Wang
1Shanghai Institute of Immunology, Shanghai Second Medical University, Shanghai 200025, China. ywang@sibs.ac.cn
Aim:
To explore the effect of turtle blood extract on murine immune system.
Methods:
We compared the ratio of CD4(+) helper T cells and CD8(+) T cells, NK cell activity, lymphocyte proliferation stimulated by mitogen and capability of cytokine secretion of cyclosphophamide-treated mice with or without treatment of turtle blood extract.
Results:
Turtle blood extract-treated mice displayed increased CD4(+) helper T cell population, stronger cytotoxicity of NK cells and enhanced of ConA-induced lymphocyte proliferation. In addition, the capacity of IFN-gamma secretion was dramatically up-regulated in turtle blood extract-treated mice group.
Conclusion:
Turtle blood extract can upregulate the immune function of cyclosphophamide-treated mouse.