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Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
[Correlation between activation-induced cytidine deaminase gene polymorphism and atopic asthma and plasma IgE in
Tian-pen Cui1, Lin Wang, Wei-chao Jiang
1Institute of Immunology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. tianpencui@hotmail.com
Aim:
To explore whether the activation-induced cytidine deaminase(AICDA) gene 8408 C/T polymorphism is related to adult atopic asthma and the level of plasma IgE.
Methods:
The polymorphism of AICDA gene was detected by PCR and restriction fragment length polymorphism (PCR-RFLP).
Results:
The frequencies of 8408T/T genotype had significant difference (P<0.05) between adult asthma patients and control group, while the frequencies of T allele between two groups were not significantly different. The total plasma IgE level in adult atopic asthma patients with 8408T/T genotype was higher than that in the patients with C/C and C/T genotypes(P<0.05).
Conclusion:
The 8408 T/T genotype of AICDA is correlated with atopic asthma and total plasma IgE level in adult.
