Related Experiment Video
Updated: Jul 28, 2026

Identification of Kinase-substrate Pairs Using High Throughput Screening
Published on: August 29, 2015
An overview of the KIN1/PAR-1/MARK kinase family
Jean-Pierre Tassan1, Xavier Le Goff
1UMR6061-CNRS Génétique et Développement. IFR 97 Génomique Fonctionnelle et Santé. Université de Rennes 1, Faculté de Médecine, 2 avenue du Professeur Léon Bernard. CS34317. 35043 Rennes Cedex. France. jean-pierre.tassan@univ-rennes1.fr
Abstract:
Members of the KIN1/PAR-1/MARK kinase family are conserved from yeast to humans and share a similar primary structural organization. Several kinases of this family appear to be at the crossroads of various biological functions including cell polarity, cell cycle control, intracellular signalisation, microtubules stability and protein stability. Here we present an overview of known roles of KIN1/PAR-1/MARK kinases including pEg3 a newly identified member which is regulated during the cell cycle and is a potential regulator of the cell cycle progression. Some common modes of action can be deciphered for this protein kinase family.
Related Concept Videos
Interactions Between Signaling Pathways
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Amplifying Signals via Enzymatic Cascade
MAPK Signaling Cascades
The JAK-STAT Signaling Pathway
PI3K/mTOR/AKT Signaling Pathway
cAMP-dependent Protein Kinase Pathways

