Traceless and multifunctional linkers for the generation of small molecules on solid supports

Numerous developments in useful linkers are closely related with the advances in solid-phase organic synthesis. These linkers allow facile attachment functionalization and release molecules of interest. Designing a new anchoring group can be essential for synthesis success, especially for small molecules on solid supports. Many novel linkers have recently been developed. Traceless linkers can be excised efficiently and quantitatively when desired while leaving behind no trace of the solid-phase synthesis. However, multi-functional cleavage allows the introduction of new functionalities during cleavage from the resin.