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Related Experiment Videos

Rhinovirus in adenoid tissue.

Heikki Rihkanen1, Olli Carpén, Merja Roivainen

  • 1Department of Otorhinolaryngology and Head and Neck Surgery, Helsinki University Hospital, Turuntie 150, 02740 Espoo, Finland. heikki.rihkanen@hus.fi

International Journal of Pediatric Otorhinolaryngology
|June 9, 2004
PubMed
Summary

Rhinovirus (RV) is common in children. This study found RV frequently in adenoid tissue, especially during colder months, and linked it to middle ear effusion in children.

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Area of Science:

  • Pediatrics
  • Virology
  • Otolaryngology

Background:

  • Rhinovirus (RV) is the leading cause of acute respiratory illness in children.
  • Adenoid tissue plays a role in respiratory and immune health.
  • Understanding viral presence in adenoids is crucial for pediatric respiratory health.

Purpose of the Study:

  • To determine the prevalence of RV in pediatric adenoid tissue year-round.
  • To investigate the association between RV presence and otitis media.

Main Methods:

  • Adenoid tissue samples from 56 children were analyzed using in-situ hybridization (ISH).
  • RV specificity was confirmed with reverse transcriptase-polymerase chain reaction (RT-PCR) on 8 samples.
  • Correlation with clinical factors like middle ear effusion was assessed.

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Main Results:

  • RV RNA was detected in 45% of adenoid specimens.
  • RV prevalence was significantly higher from late fall to spring (65%) compared to late spring to early fall (20%).
  • Children with middle ear effusion showed a higher incidence of RV in adenoid tissue.

Conclusions:

  • Adenoid tissues frequently harbor RV, particularly during colder months.
  • Children with otitis media with effusion are more likely to have RV in their adenoid tissue.
  • Further research is needed to establish causality between RV and middle ear effusion.