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A case-control study of erectile dysfunction among men diagnosed with panic disorder
W A Blumentals1, A Gomez-Caminero, R R Brown
1Worldwide Epidemiology, GlaxoSmithKline Pharmaceuticals, Collegeville, Pennsylvania 19426, USA.
International Journal of Impotence Research
|June 9, 2004
Summary
Men with panic disorder have an increased risk of erectile dysfunction (ED). However, when panic disorder precedes ED, it is associated with a reduced risk of ED after accounting for other health conditions.
Area of Science:
- Psychiatry
- Urology
- Health Informatics
Background:
- Panic disorder is a common anxiety disorder.
- Erectile dysfunction (ED) affects a significant number of men.
- The relationship between panic disorder and ED requires further investigation.
Purpose of the Study:
- To examine the association between panic disorder and erectile dysfunction (ED) in a large managed care population.
- To assess the risk of ED in men with panic disorder, considering comorbid conditions and comedications.
Main Methods:
- Utilized the Integrated Healthcare Information Services National Managed Care Benchmark Database (IHCIS), a de-identified database of over 17 million lives.
- Included 60,949 ED cases and 243,796 controls for analysis.
- Employed unconditional logistic regression to calculate crude and adjusted odds ratios (ORs) for ED risk.
Main Results:
- Men with panic disorder showed a more than two-fold increased risk of ED (OR=2.29).
- After adjusting for comorbidities and comedications, the risk of ED remained elevated (OR=1.33).
- When panic disorder preceded ED diagnosis, adjusted analyses revealed a significant risk reduction for ED (OR=0.65).
Conclusions:
- Panic disorder is associated with an increased risk of ED.
- The temporal relationship between panic disorder and ED is crucial; when panic disorder precedes ED, it may be linked to a protective effect against ED.
- Further research is warranted to understand the complex interplay between panic disorder and ED.