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Updated: Aug 24, 2026

Non-enzymatic, Serum-free Tissue Culture of Pre-invasive Breast Lesions for Spontaneous Generation of Mammospheres
Published on: November 8, 2014
Spiradenocarcinoma of the breast arising in a long-standing spiradenoma
Alfredo Ribeiro-Silva1, Catarina Shaletich, Renata Scarpat Careta
1Department of Pathology and Laboratory of Surgical Pathology/Cytopathology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Avenida Bandeirantes s/n, Campus Universitário Monte Alegre, 14048-900 Ribeirão Preto, São Paulo, Brazil.
Abstract:
The embryologic origin of the breast is related to salivary and sweats glands. Thus, breast neoplasms may show differentiation toward these tissues, although this is a rare event in humans. We report the clinicopathologic and immunohistochemical features of a 57-year-old woman presenting with a spiradenoma that originated in breast tissue and became malignant 40 years later. Some histogenetic concepts relevant to this case are discussed, along with a brief review of this neoplasm.
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