Related Experiment Video
Updated: Aug 24, 2026

07:17
An Orthotopic Resectional Mouse Model of Pancreatic Cancer
Published on: September 24, 2020
Renal metastasis from pancreatic adenocarcinoma
Lorenzo Martino1, Francesco Martino, Antonio Coluccio
1Department of Urology, Hospital of Chiari, Brescia, Italy. lomagaba@libero.it
Abstract:
The Authors describe a case of a man (68 years) affected by renal metastasis from pancreatic adenocarcinoma. Additional metastases had been detected in the liver, in the spleen and in the small intestine. The man underwent radical nephrectomy (to prevent hematuria), splenectomy and biopsies in liver and small intestine. After surgery the patient refused adjuvant chemotherapy.
Related Concept Videos
Metastasis
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Acute Pancreatitis II: Pathophysiology
The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...

