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Updated: Aug 24, 2026

Pulsed Wave Doppler Assessment of Diastolic Dysfunction in the ZSF-1 Rat Model of Pulmonary Hypertension Due to Left Heart Disease
Published on: May 22, 2026
Diastolic heart failure
Maria Frigerio1, Giovanni Aguggini
1Division of Cardiology 2, A. De Gasperis Cardio-Thoracic-Vascular Department, Nigularda Ca' Granda Hospital, Milan, Italy. maria.frigerio@ospedaleniguarda.it
Insights
Diastolic heart failure, characterized by preserved left ventricular ejection fraction (LVEF), is common in the elderly. While mortality is lower than other heart failure types, morbidity remains high, necessitating empirical treatments.
Area of Science:
- Cardiology
- Internal Medicine
Background:
- Diastolic heart failure (DHF) is defined by preserved left ventricular ejection fraction (LVEF).
- It is a common and heterogeneous condition, particularly prevalent in the elderly, accounting for up to 50% of heart failure cases in this demographic.
- While DHF generally has lower mortality rates compared to heart failure with reduced LVEF, its morbidity is substantial.
Purpose of the Study:
- To summarize the characteristics and current treatment approaches for diastolic heart failure.
Main Methods:
- Review of existing literature and clinical guidelines on diastolic heart failure.
- Emphasis on diagnostic methods like Doppler echocardiography for identifying diastolic dysfunction.
- Discussion of pharmacological interventions used in managing DHF.
Main Results:
- Diastolic dysfunction is a key diagnostic criterion for DHF, often identified via Doppler echocardiography.
- Heart failure with preserved LVEF is particularly common in older adults.
- Treatment strategies are empirical, focusing on hemodynamic management and disease progression control.
Conclusions:
- Diastolic heart failure presents unique challenges due to its high morbidity despite lower mortality.
- Current treatments are empirical and focus on symptom management and hemodynamic stabilization.
- Further research into targeted therapies for DHF is warranted.
Abstract:
Diastolic heart failure is characterized by the presence of heart failure with preserved left ventricular ejection fraction (LVEF): documentation of diastolic dysfunction, usually by Doppler echocardiography, is strongly recommended. Heart failure with preserved LVEF is a heterogeneous and common condition, especially in the elderly, among whom represents up to 50% of all heart failure patients. Mortality is generally lower than in patients with heart failure and low LVEF, and depends on etiology, patient conditions, and comorbidities. Anyway, morbidity is very high. So far, treatment of diastolic heart failure is empirical, and is aimed to maintain cardiac output, reduce filling pressure, control heart rate and rhythm, and antagonize disease progression with diuretics, inhibitors of the renin-angiotensin-aldosterone system, nitrates, and digoxin.
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