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Related Experiment Videos

Pellucid marginal degeneration and scleroderma.

Freda Sii1, Graham A Lee, Paul Sanfilippo

  • 1City Eye Centre, Level 10, 135 Wickham Terrace, Brisbane, QLD, 4000, Australia.

Clinical & Experimental Optometry
|June 10, 2004
PubMed
Summary

Systemic scleroderma, a connective tissue disease, can affect the eyes. This case highlights a rare association with pellucid marginal degeneration, causing corneal thinning and astigmatism.

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Area of Science:

  • Ophthalmology
  • Rheumatology
  • Corneal Diseases

Background:

  • Systemic scleroderma is a multi-system connective tissue disease with known ocular manifestations.
  • Pellucid marginal degeneration is a rare, bilateral corneal ectasia characterized by peripheral thinning and astigmatism.
  • No prior associations between systemic scleroderma and pellucid marginal degeneration have been reported.

Observation:

  • A 55-year-old woman with systemic scleroderma presented with rapidly progressing against-the-rule astigmatism.
  • The patient exhibited symptoms suggestive of peripheral corneal thinning.
  • Ocular involvement in systemic scleroderma typically includes dry eye and eyelid abnormalities.

Findings:

  • This case presents a potential, previously unreported association between systemic scleroderma and pellucid marginal degeneration.

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  • The patient's rapidly progressing astigmatism was a key indicator of corneal ectasia.
  • The findings underscore the importance of considering rare corneal conditions in patients with systemic diseases.

    • Implications:

    • This case expands the spectrum of ocular complications associated with systemic scleroderma.
    • Early diagnosis and management of pellucid marginal degeneration are crucial to prevent vision loss.
    • Further research is warranted to investigate the potential link between systemic scleroderma and pellucid marginal degeneration.