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Granuloma multiforme.

Kamaldeep Sandhu1, Abir Saraswat, Somesh Gupta

  • 1Department of Dermatology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India.

International Journal of Dermatology
|June 10, 2004
PubMed
Summary
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This study highlights granuloma multiforme, a rare skin condition presenting as annular lesions. Histopathology confirms the diagnosis, differentiating it from similar dermatological conditions.

Area of Science:

  • Dermatology
  • Pathology
  • Immunology

Background:

  • Granuloma multiforme is a rare inflammatory skin condition.
  • Differentiating it from granuloma annulare and sarcoidosis is crucial for accurate diagnosis and management.
  • Understanding the histopathological features is key to diagnosis.

Observation:

  • Two cases of granuloma multiforme are presented, featuring annular, polycyclic lesions with erythematous borders on the chest, neck, and hands.
  • Lesions varied in size and showed central clearing and minimal atrophy.
  • Patients reported burning sensations and pruritus, with no systemic symptoms or nerve involvement.

Findings:

  • Skin biopsies revealed histiocytic granulomas with collagen degeneration, necrobiosis, and multinucleated giant cells.

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  • Inflammatory infiltrates included histiocytes and lymphocytes.
  • Absence of acid-fast bacilli ruled out other granulomatous infections.

    • Implications:

    • This case series emphasizes the importance of histopathological examination for diagnosing granuloma multiforme.
    • Accurate diagnosis aids in appropriate patient management and distinguishes it from other granulomatous dermatoses.
    • Further research may elucidate the specific etiology and pathogenesis of this condition.