Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The decrease in plasma ghrelin concentrations following bariatric surgery depends on the functional integrity of the

Gema Frühbeck1, Alberto Diez-Caballero, M Jesús Gil

  • 1Metabolic Research Laboratory, Clínica Universitaria de Navarra, University of Navarra, Pamplona, Spain. gfruhbeck@unav.es

Obesity Surgery
|June 10, 2004
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Ghrelin-LEAP2 System in Obesity and Diabetes: Pathophysiological Roles and Therapeutic Potential.

Current obesity reports·2026
Same author

Assessing Europe's policy readiness to confront the MASLD/MASH public health threat.

The Lancet regional health. Europe·2026
Same author

Framework for the pharmacological treatment of obesity and its complications from the European Association for the Study of Obesity (EASO): 2026 update.

Nature medicine·2026
Same author

An adipocyte-endothelial framework to identify molecular signatures of metabolic vulnerability in obesity.

Research square·2026
Same author

FNDC4 and FNDC5 Attenuate SARS-CoV-2 S1-Induced Inflammatory Responses in Human Adipose Tissue.

European journal of clinical investigation·2026
Same author

Ultrasound assessment of abdominal fat: Subcutaneous maximum thickness as a practical marker of metabolic risk in primary care.

Journal of diabetes and its complications·2026

Gastric bypass surgery significantly impacts ghrelin levels, with Roux-en-Y gastric bypass showing the greatest reduction. The surgical method influences appetite regulation by affecting the stomach fundus.

Area of Science:

  • Bariatric surgery
  • Endocrinology
  • Gastroenterology

Background:

  • Gastric bypass surgery reduces stomach pouch size, suppressing ghrelin.
  • The fundus produces ghrelin, a hormone influencing food intake.
  • Bariatric surgery's impact on fundic factors in appetite signaling was investigated.

Purpose of the Study:

  • To compare the effects of adjustable gastric banding (AGB), Roux-en-Y gastric bypass (RYGBP), and biliopancreatic diversion (BPD) on ghrelin concentrations.
  • To assess how different bariatric procedures affect weight loss and hormonal profiles.
  • To understand the role of the stomach fundus in appetite regulation post-surgery.

Main Methods:

  • Studied 16 obese patients who underwent AGB, RYGBP, or BPD with similar weight loss.

Related Experiment Videos

  • Collected blood for biochemical and hormonal analyses.
  • Assessed body composition using air-displacement plethysmography.

    • Main Results:

    • All procedures achieved comparable weight loss and body fat reduction.
    • RYGBP significantly reduced fasting plasma ghrelin concentrations compared to AGB and BPD.
    • No significant differences were observed in BMI, body fat, glucose, triglycerides, cholesterol, insulin, or leptin levels between groups.

    Conclusions:

    • Fasting ghrelin concentrations after bariatric surgery depend on the degree of stomach fundus dysfunction.
    • RYGBP leads to a more pronounced suppression of ghrelin compared to AGB and BPD.
    • The surgical technique influences appetite regulation through its effect on the stomach fundus.