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Translesion DNA synthesis: little fingers teach tolerance
1Institute of Molecular Cancer Research, University of Zürich, August-Forel Strasse 7, CH-8008 Zürich, Switzerland.
Current Biology : CB
|June 10, 2004
Abstract:
DNA synthesis on a damaged template requires tolerant DNA polymerases. Crystallographic analysis has captured a Y-family polymerase synthesizing across an abasic site, providing insight into the mechanisms of DNA damage tolerance and mutation.
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