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Approximate equivalent rosuvastatin doses for temporary statin interchange programs
Michael G Kendrach1, Maisha Kelly-Freeman
1Department of Pharmacy Practice; Samford University Global Drug Information Service, McWhorter School of Pharmacy, Samford University, Birmingham, AL 35229-7027, USA. mgkrendra@samford.edu
The Annals of Pharmacotherapy
|June 10, 2004
Summary
Rosuvastatin is not equivalent to other statins on a milligram-to-milligram basis. This cholesterol-lowering drug is significantly more potent than atorvastatin, simvastatin, pravastatin, and lovastatin.
Area of Science:
- Pharmacology
- Cardiovascular Medicine
Background:
- Hydroxymethylglutaryl coenzyme A reductase inhibitors (statins) are widely prescribed for cholesterol management.
- Rosuvastatin is a potent statin, but its precise dose equivalence to other statins is not well-established for substitution purposes.
Purpose of the Study:
- To determine approximate equivalent doses of rosuvastatin compared to other statins.
- To inform temporary substitution programs within lipid-lowering therapy.
Main Methods:
- A comprehensive literature search was performed to identify direct comparative clinical trials.
- Evaluated trials focused on the magnitude of cholesterol reduction between rosuvastatin and other statins.
Main Results:
- Mean low-density lipoprotein (LDL) and total cholesterol values were analyzed from selected clinical trials.
- Results demonstrated that rosuvastatin is not equivalent to other statins on a milligram-per-milligram basis.
Conclusions:
- Rosuvastatin exhibits higher potency than other statins.
- It is estimated to be at least 2 times as potent as atorvastatin and 4 times as potent as simvastatin.
- Rosuvastatin is at least 8 times more potent than pravastatin and lovastatin.