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Diabetes and hepatitis frequency in 140 lichen planus cases in Cukurova region

Y Gül Denli1, Murat Durdu, Mehmet Karakas

  • 1Cukurova University, Faculty of Medicine, Department of Dermatology, Adana, Turkey.

The Journal of Dermatology
|June 10, 2004
PubMed

Insights

Lichen planus (LP) cases showed higher frequencies of Hepatitis C Virus (HCV) compared to controls. Further studies are needed to confirm significant associations between Hepatitis B Virus (HBV), diabetes mellitus (DM), and LP.

Area of Science:

  • Dermatology
  • Hepatology
  • Endocrinology

Background:

  • Lichen planus (LP) is an inflammatory condition affecting skin and mucous membranes.
  • Potential associations between LP and viral infections like Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV), as well as metabolic disorders like diabetes mellitus (DM), warrant investigation.

Purpose of the Study:

  • To determine the frequencies of HBV, HCV, and DM in patients diagnosed with LP.
  • To compare these frequencies with a control group to assess potential co-associations.

Main Methods:

  • Retrospective review of 260 LP cases diagnosed between 1997 and 2002.
  • Comparison of HBV, HCV, and DM prevalence with a control group of patients with other dermatoses.
  • Hepatitis serology and blood glucose levels were examined in a subset of LP cases.

Main Results:

  • HBV positivity was found in 17.1% of LP cases versus 7.1% in controls.
  • Anti-HCV positivity was observed in 5% of LP cases versus 1.4% in controls.
  • DM was present in 15.7% of LP cases versus 7.1% in controls.

Conclusions:

  • A significant co-association between LP and HCV is suggested.
  • While co-associations with HBV and DM were noted, further research is required to establish their statistical significance.
  • Clinical and racial characteristics may influence the observed co-association ratios.

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