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Antinociceptive profile of 2-phenylselenenyl-1,8-cineole in mice
Damião Pergentino de Sousa1, Ellen Raphael, Ursula Brocksom
1Laboratório de Química Bio-Orgânica, Departamento de Química, Universidade Federal de São Carlos, Sao Carlos, Sao Paulo State, Brazil.
Biological & Pharmaceutical Bulletin
|June 10, 2004
Abstract:
2-Phenylselenenyl-1,8-cineole (PSC) increased both the pentobarbital-induced sleeping time and the reaction time (up to 2 h) in the tail immersion method. PSC also caused dose-dependent inhibition of acetic acid induced writhing with maximum inhibition of 93.4% and was approximately 8.5-fold more potent than 1,8-cineole. These findings show that PSC presents sedative effect and significant antinociceptive activity.