Related Experiment Video
Updated: Jul 11, 2026

A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats
Published on: December 2, 2016
Coarctation of the aorta: a secondary cause of hypertension
L M Prisant1, Kwabena Mawulawde, Deepak Kapoor
1Department of Hypertension and Clinical Pharmacology, Medical College of Georgia, Augusta, GA 30912, USA. mprisant@mail.mcg.edu
Insights
Coarctation of the aorta is a narrowing of the aorta, often congenital. Early diagnosis and treatment are crucial to prevent serious complications like heart failure and aortic rupture.
Area of Science:
- Cardiology
- Pediatric Cardiology
- Vascular Surgery
Background:
- Coarctation of the aorta is a congenital narrowing of the aortic arch.
- It is frequently associated with other congenital heart defects.
- Untreated, the mean age of death is 34 years due to severe cardiovascular complications.
Observation:
- Symptoms may be absent in adults, necessitating vigilant examination.
- Key diagnostic clues include diminished femoral pulses, systolic murmurs, and posterior rib notching on chest X-ray.
- Two-dimensional echocardiography with Doppler confirms the diagnosis.
Findings:
- Surgical repair and percutaneous intervention are effective treatments for aortic coarctation.
- Hypertension may persist even after successful repair.
- Late complications include recoarctation, aortic aneurysm, and cerebrovascular accidents.
Implications:
- Coarctation of the aorta requires lifelong monitoring for potential late complications.
- Effective management strategies are essential to improve long-term patient outcomes.
- Further research into preventing and managing persistent hypertension post-intervention is warranted.
Abstract:
Coarctation of the aorta is a constriction of the aorta located near the ligamentum arteriosum and the origins of the left subclavian artery. This condition may be associated with other congenital disease. The mean age of death for persons with this condition is 34 years if untreated, and is usually due to heart failure, aortic dissection or rupture, endocarditis, endarteritis, cerebral hemorrhage, ischemic heart disease, or concomitant aortic valve disease in uncomplicated cases. Symptoms may not be present in adults. Diminished and delayed pulses in the right femoral artery compared with the right radial or brachial artery are an important clue to the presence of a coarctation of the aorta, as are the presence of a systolic murmur over the anterior chest,bruits over the back, and visible notching of the posterior ribs on a chest x-ray. In many cases a diagnosis can be made with these findings. Two-dimensional echocardiography with Doppler interrogation is used to confirm the diagnosis. Surgical repair and percutaneous intervention are used to repair the coarctation; however, hypertension may not abate. Because late complications including recoarctation, hypertension, aortic aneurysm formation and rupture, sudden death, ischemic heart disease, heart failure, and cerebrovascular accidents may occur, careful follow-up is required.
Related Concept Videos
Hypertension and Regulation of Blood Pressure
Aortic Regurgitation II: Clinical Features and Diagnostic Tests
Hypertension I: Introduction
Hypertension II: Pathophysiology
Hypertension III: Clinical Manifestations and Diagnostic Studies
Aneurysm II: Clinical Manifestations and Diagnostic Studies

