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Decrease in left ventricular ejection time on digital arterial waveform during simulated hypovolemia in normal

Thomas Geeraerts1, Pierre Albaladejo, Adrien Descorps Declère

  • 1Department of Anesthesiology and UPRES 3540, Hôpital de Bicêtre, Le Kremlin Bicêtre, France.

The Journal of Trauma
|June 10, 2004
PubMed
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Peripheral left ventricular ejection time (LVET) can reflect central LVET changes during hypovolemia. This noninvasive measurement offers a reliable method for monitoring reduced blood volume.

Area of Science:

  • Cardiovascular Physiology
  • Hemodynamics
  • Noninvasive Monitoring

Background:

  • Left ventricular ejection time (LVET) is altered during hypovolemia.
  • Central arterial pulse wave modifications during hypovolemia are not fully understood.
  • Comparison of central and peripheral arterial pulse wave changes during hypovolemia is needed.

Purpose of the Study:

  • To compare modifications of the pulse wave in central (carotid) and peripheral (digital) arteries during central hypovolemia.
  • To assess the utility of peripheral LVET as a noninvasive indicator of hypovolemia.

Main Methods:

  • Nine healthy volunteers underwent progressive lower body negative pressure (LBNP) to induce hypovolemia.
  • Carotid arterial pressure waveforms were recorded using tonometry.

Related Experiment Videos

  • Digital pulse waves and stroke volume were measured using volume-clamp and thoracic impedance methods, respectively.
  • Main Results:

    • Mean arterial pressure remained stable.
    • Heart rate increased and stroke volume decreased significantly with LBNP.
    • Both carotid and digital LVET decreased significantly at -10 mm Hg LBNP.

    Conclusions:

    • Peripheral LVET variations correlate with central LVET changes during LBNP.
    • Digital LVET is a potentially reliable noninvasive parameter for monitoring hypovolemia.