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Management of nonfunctioning islet cell tumors
Han Liang1, Pu Wang, Xiao-Na Wang
1Department of Gastrointestinal Oncological Surgery, Tianjin Cancer Hospital, Tianjin Medical University, Hexi District, Tianjin 300060, China. hanliang86@yahoo.com
World Journal of Gastroenterology
|June 10, 2004
Summary
Nonfunctioning islet cell tumors (NFICTs) primarily affect young women. Surgical resection, particularly curative, yields good long-term outcomes for these pancreatic tumors.
Area of Science:
- Endocrinology
- Surgical Oncology
- Gastroenterology
Background:
- Nonfunctioning islet cell tumors (NFICTs) are rare pancreatic neoplasms.
- Understanding their characteristics is crucial for effective management.
Purpose of the Study:
- To define the clinical and pathological features of NFICTs.
- To review institutional experience with diagnosis and treatment over 30 years.
Main Methods:
- Retrospective review of 43 patients with confirmed NFICTs.
- Survival analysis using Kaplan-Meier and log-rank tests.
Main Results:
- NFICTs predominantly found in young women (mean age 31.63).
- Common symptoms include abdominal pain and nausea/vomiting.
- Surgical resection was performed in 91% of patients, with curative rates of 70%.
- Overall 5- and 10-year survival rates for nonfunctioning islet cell carcinoma (NFICC) were 58.05% and 29.03% respectively.
- Radical operation was an independent positive prognostic factor.
Conclusions:
- NFICTs are more common in young women.
- Good long-term results are observed following surgical intervention, especially curative resection.