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Updated: Aug 24, 2026
Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
Published on: September 18, 2020
Comparison of nuclear matrix proteins between gastric cancer and normal gastric tissue
Qin-Xian Zhang1, Yi Ding, Zhuo Li
1Molecular Cell Biology Research Center, Medical College of Zhengzhou University, 40 Daxue Lu, Zhengzhou 450052, Henan Province, China. qxz53@zzu.edu.cn
Aim:
To study the alteration of nuclear matrix proteins (NMPs) in gastric cancer.
Methods:
The NMPs extracted from 22 cases of gastric cancer and normal gastric tissues were investigated by SDS-PAGE technique and the data were analyzed using Genetools analysis software.
Results:
Compared with normal gastric tissue, the expression of 30 ku and 28 ku NMPs in gastric cancer decreased significantly (P=0.002, P=0.001, P<0.05). No significant difference was found in the expression of the two NMPs between the various differentiated grades (P=0.947, P=0.356) and clinical stages of gastric cancer (P=0.920, P=0.243, P>0.05).
Conclusion:
The results suggested that the alteration of NMPs in gastric cancer occurred at the early stage of gastric cancer development.
