Related Experiment Video

Updated: Aug 24, 2026

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

[Predictive factors of deteriorating left ventricular function after direct percutaneous coronary intervention for

Toshiro Katayama1, Hiroshi Nakashima, Shinnosuke Furudono

  • 1Department of Cardiology, Nagasaki Citizens Hospital, Nagasaki.

Journal of Cardiology
|June 11, 2004
PubMed

Insights

Diabetes mellitus is a key predictor of reduced left ventricular ejection fraction (LVEF) after acute myocardial infarction treated with percutaneous coronary intervention. This finding highlights the importance of managing diabetes in cardiac patients.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Clinical Research

Context:

  • Acute myocardial infarction (AMI) management.
  • Direct percutaneous coronary intervention (PCI) effectiveness.
  • Left ventricular function assessment post-AMI.

Purpose:

  • Identify predictors of left ventricular function deterioration after primary PCI in AMI.
  • Evaluate the relationship between left ventricular remodeling and LVEF changes.
  • Determine the role of diabetes mellitus in post-PCI cardiac outcomes.

Summary:

  • This study analyzed 96 patients with first anterior AMI undergoing primary PCI.
  • Left ventricular ejection fraction (LVEF) was assessed acutely and chronically.
  • Diabetes mellitus was identified as the sole independent predictor of LVEF reduction (OR 4.44, p=0.02).

Impact:

  • Highlights diabetes mellitus as a critical factor influencing recovery after primary PCI for AMI.
  • Underscores the link between LVEF reduction and left ventricular remodeling.
  • Informs clinical strategies for managing diabetic patients with AMI to improve cardiac outcomes.
Abstract

Related Concept Videos

Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...