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[Clinical, biochemical and ultrasonic changes in the liver in small intestine enzymopathy in children]

I O Uvarova, A T Kamilova, A N Aripov

    Klinicheskaia Laboratornaia Diagnostika
    |June 11, 2004
    PubMed

    Insights

    Children with small intestine enzymopathy variations (ESI) show distinct liver and hepatobiliary disorders. Fat hepatosis was more frequent in celiac disease than celiac syndrome, informing pediatric therapy.

    Area of Science:

    • Pediatric Gastroenterology
    • Hepatology
    • Clinical Nutrition

    Background:

    • Small intestine enzymopathy variations (ESI) encompass primary celiac enzymopathy (CE), celiac syndrome, and disaccharidase insufficiency syndrome (DIS).
    • Children with ESI often present with overlapping clinical signs, complicating diagnosis and management.
    • Liver and hepatobiliary system involvement can occur in pediatric ESI.

    Purpose of the Study:

    • To investigate and compare liver and hepatobiliary system disorders in children with different types of ESI.
    • To identify specific ultrasound findings differentiating celiac disease from celiac syndrome.
    • To inform rational diet and drug therapy for pediatric ESI.

    Main Methods:

    • Prospective follow-up of 70 pediatric patients (aged 1-11 years).
    • Categorization into primary celiac enzymopathy (CE, n=30), celiac syndrome (n=20), and disaccharidase insufficiency syndrome (DIS, n=30).
    • Clinical sign assessment and ultrasound examination for liver and hepatobiliary evaluation, specifically noting fat hepatosis.

    Main Results:

    • Distinct liver and hepatobiliary disorders were observed in children across the ESI spectrum.
    • Fat hepatosis was identified more frequently in children with celiac disease compared to those with celiac syndrome.
    • While clinical signs were generally similar, ultrasound findings showed differences in the prevalence of fat hepatosis.

    Conclusions:

    • Children with ESI exhibit varied liver and hepatobiliary system pathologies.
    • Ultrasound detection of fat hepatosis can help differentiate celiac disease from celiac syndrome in pediatric patients.
    • These findings support tailored diet and drug therapy approaches for children diagnosed with ESI.

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