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Synthesis and antimicrobial activity of new 5-aryl-2-hydroxy-3(2H)-pyrrolinone derivatives
V O Kozminykh1, N M Igidov, E N Kozminykh
1Pharmaceutical Institute, Faculty of Chemistry, Perm University, Russia.
Die Pharmazie
|April 1, 1992
Abstract:
The synthesis of some 1-substituted 5-aryl-2-hydroxy-2-methoxycarbonylmethyl-3(2H)-pyrrolinones is described. The results of microbiological screening are given. They indicate that 2-methylene-3(2H)-furanone and 2-hydroxy-3(2H)-pyrrolinone derivatives exhibit a rather low antimicrobiological activity.