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Controlled-release tablet formulation of isoniazid
N K Jain1, K Kulkarni, N Talwar
1Department of Pharmaceutical Sciences, University of Saugor, Sagar, India.
Die Pharmazie
|April 1, 1992
Abstract:
Guar (GG) and Karaya gums (KG) alone and in combination with hydroxy-propylmethylcellulose (HPMC) were evaluated as release retarding materials to formulate a controlled-release tablet dosage form of isoniazid (1). In vitro release of 1 from tablets followed non-Fickian release profile with rapid initial release. Urinary excretion studies in normal subjects showed steady-state levels of 1 for 13 h. In vitro and in vivo data correlated (r = 0.9794). The studies suggested the potentiality of GG and KG as release retarding materials in formulating controlled-release tablet dosage forms of 1.