Related Experiment Videos
[Relationship between chemical structure and toxicologic-pharmacokinetic properties of new ampicillin derivatives]
H Willitzer1, U Horn, L Heinisch
1Institut für Mikrobiologie und experimentelle Therapie (ZIMET), Jena.
Die Pharmazie
|July 1, 1992
Abstract:
The toxicity and the bioavailability of new ampicillin derivatives with glyoxylic acid benzhydrazones as site chain depend on the hydrophobic properties of the site chain. Substituents with lower hydrophobicity (expressed by the hydrophobic substituent constant pi according to Hansch) show a lower toxicity (maximal tolerated doses) and also a lower bioavailability.