Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A subharmonic dynamical bifurcation during in vitro epileptiform activity.

Jose L Perez Velazquez1, Houman Khosravani

  • 1Brain and Behavior Programme, Division of Neurology, Hospital for Sick Children, Department of Paediatrics, University of Toronto, Toronto, Ontario M5G 1X8, Canada. jlpv@sickkids.ca

Chaos (Woodbury, N.Y.)
|June 11, 2004
PubMed
Summary

Epileptic seizures may arise from altered neural network synchronization. Our study reveals intermittency as a key dynamical regime underlying seizure activity, offering insights into brain network dynamics.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Expert Consensus Statement on Acoustic Metrics for Swallowing Dysfunction Screening in Older Adults: A Delphi Study.

Journal of voice : official journal of the Voice Foundation·2026
Same author

AcT Trial: Protocol for a Pragmatic Registry-Linked Randomized Clinical Trial.

Stroke (Hoboken, N.J.)·2026
Same author

Intravenous Thrombolysis at Primary Stroke Centers Versus Comprehensive Stroke Centers: Analysis From the AcT Trial.

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques·2026
Same author

Innovations in Thrombectomy Training: A Systematic Review and Expert Recommendations from the Society of Vascular and Interventional Neurology-Mission Thrombectomy Initiative.

Stroke (Hoboken, N.J.)·2026
Same author

Cerebral Amyloid Angiopathy Imaging Markers, Radiological Boston Criteria, and Thrombolysis Outcomes in Ischemic Stroke.

Stroke·2026
Same author

Society of Vascular and Interventional Neurology (SVIN) Stroke Interventional Laboratory Consensus (SILC) Criteria for Training Standards and Maintenance of Certification in Neurointervention.

Stroke (Hoboken, N.J.)·2026

Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Dynamical Systems Theory

Background:

  • Epileptic seizures are linked to abrupt changes in neuronal synchronization within brain networks.
  • Understanding the underlying dynamics of seizure generation is crucial for developing effective treatments.

Purpose of the Study:

  • To investigate the dynamical regimes associated with seizure-like activity using an in vitro model of status epilepticus (SE).
  • To characterize neuronal population activity during seizure transitions and within seizures.

Main Methods:

  • Utilized an in vitro model of status epilepticus (SE).
  • Analyzed time intervals between neuronal spikes or bursts to construct first-return interval plots.
  • Employed return maps to approximate local system dynamics preceding seizures.

Related Experiment Videos

Main Results:

  • First-return map analysis indicated that intermittency is a dynamical regime underlying observed epileptic activity.
  • The study successfully characterized dynamical regimes during seizure onset and progression.

Conclusions:

  • Intermittency appears to be a significant dynamical mechanism contributing to epileptic activity.
  • The employed analytical approach, using interval plots and return maps, shows promise for understanding neuronal population dynamics in both healthy and diseased brains.