Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Low and high circulating cortisol levels predict mortality and cognitive dysfunction early after stroke.

N Marklund1, M Peltonen, T K Nilsson

  • 1Department of Neuroscience and Neurosurgery, Uppsala University, Uppsala University Hospital, Uppsala, Sweden. niklas.marklund@neurokir.uu.se

Journal of Internal Medicine
|June 11, 2004
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Management of chronic subdural hematoma: a consensus statement from the 2024 Copenhagen joint iCORIC/DACSUHS symposium.

Acta neurochirurgica·2026
Same author

A core outcome set for cranioplasty following stroke or traumatic brain injury - The COAST study.

Brain & spine·2025
Same author

Bariatric surgery, osteoarthritis and arthroplasty of the hip and knee in Swedish Obese Subjects - up to 31 years follow-up of a controlled intervention study.

Osteoarthritis and cartilage·2023
Same author

Milk intake and incident stroke and CHD in populations of European descent: a Mendelian randomisation study.

The British journal of nutrition·2021
Same author

Remission and progression of pre-existing micro- and macroalbuminuria over 15 years after bariatric surgery in Swedish Obese Subjects study.

International journal of obesity (2005)·2020
Same author

Elevated adiponectin predicts the development of rheumatoid arthritis in subjects with obesity.

Scandinavian journal of rheumatology·2020

High cortisol levels after stroke are linked to confusion and worse outcomes. Both very high and very low cortisol levels increase mortality risk within a year, while dehydroepiandrosterone sulphate (DS) levels did not correlate with patient outcomes.

Area of Science:

  • Neuroendocrinology
  • Stroke Medicine
  • Clinical Chemistry

Background:

  • Elevated cortisol is linked to confusion and poor outcomes post-stroke.
  • Dehydroepiandrosterone sulphate (DS) may possess anti-glucocorticoid properties.
  • Steroid hormone dysregulation can impact brain function and neuronal survival.

Purpose of the Study:

  • To investigate serum cortisol and DS levels early after ischemic stroke.
  • To examine the relationship between cortisol/DS ratio and disorientation.
  • To assess the association of these hormone levels with short-term and long-term mortality.

Main Methods:

  • 88 acute ischemic stroke patients and 65 healthy controls were studied.
  • Serum cortisol (C) and DS levels were measured on days 1 and/or 4.

Related Experiment Videos

  • Multivariate logistic regression analyzed mortality, adjusting for clinical factors.

    • Main Results:

    • Stroke patients showed no difference in day 1 cortisol compared to controls.
    • Higher day 1 cortisol levels were associated with acute disorientation.
    • Both low (<270 nmol/L) and high (>550 nmol/L) cortisol levels predicted increased 1-year mortality.

    Conclusions:

    • Hypercortisolism is associated with early cognitive dysfunction after ischemic stroke.
    • Both high and low cortisol levels correlate with increased post-stroke mortality.
    • Dehydroepiandrosterone sulphate (DS) levels were not significantly associated with clinical outcomes.