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[Effectiveness of omeprazole therapy in children with gastroesophageal reflux diseases(GERD)]

Mieczysława Czerwionka-Szaflarska1, Grazyna Mierzwa, Renata Kuczyńska

  • 1Katedra i Klinika Pediatrii, Alergologii i Gastroenterologii Akademii Medycznej w Bydgoszczy.

Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego
|June 12, 2004
PubMed

Insights

Omeprazole (Polprazol) effectively treats gastroesophageal reflux disease (GERD) in children. This therapy significantly reduced common GERD symptoms like heartburn and abdominal pain in pediatric patients.

Area of Science:

  • Pediatric Gastroenterology
  • Pharmacology

Background:

  • Gastroesophageal reflux disease (GERD) is common in children.
  • Symptoms include regurgitation, heartburn, and abdominal pain, impacting quality of life.

Purpose of the Study:

  • To evaluate the efficacy of omeprazole (Polprazol) in treating pediatric GERD.
  • To analyze the impact of omeprazole on key GERD symptoms in children.

Main Methods:

  • Retrospective analysis of 78 children diagnosed with GERD.
  • Diagnosis confirmed via questionnaires, pH-metry, and/or endoscopy.
  • Treatment involved omeprazole at 0.5-1.0 mg/kg daily.

Main Results:

  • Pre-treatment symptoms: regurgitation (94%), heartburn (84%), vomiting (38%), abdominal pain (90%).
  • After 8 weeks of omeprazole, symptom reduction was significant:
  • Regurgitation (31%), heartburn (28%), vomiting (5%), abdominal pain (26%).

Conclusions:

  • Omeprazole therapy demonstrates significant efficacy in managing GERD symptoms in children.
  • The study supports omeprazole as an effective treatment option for pediatric GERD.
Abstract

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