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Updated: Aug 24, 2026
Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
[Immunobiomarkers in healthy children from two Polish cities]
Piotr Imiołek1, Renata Złotkowska, Jan E Zejda
1Zakład Epidemiologii Instytutu Medycyny Pracy i Zdrowia Srodowiskowego w Sosnowcu. pimiolek@poczta.onet.pl
Insights
This study established reference values for lymphocyte subpopulations and immunoglobulin concentrations in Polish children aged 9-11. The findings align with global data, highlighting the need for a comprehensive pediatric immunobiomarker database.
Area of Science:
- Immunology
- Pediatrics
- Environmental Health
Background:
- Assessing the immune system relies on lymphocyte subpopulation and immunoglobulin levels.
- Establishing pediatric reference values requires large-scale studies across diverse populations.
- The Central European Study of Air pollution and Respiratory Health (CESAR) aimed to address this need.
Purpose of the Study:
- To determine lymphocyte subpopulation values and immunoglobulin concentrations in Polish children.
- To compare these findings with international data.
- To contribute to a global database of pediatric immunobiomarkers.
Main Methods:
- Examined 80 healthy children aged 9-11 from two Polish cities (Swietochlowice and Pszczyna).
- Data collected as part of the CESAR initiative.
- Results compared with existing literature from global studies.
Main Results:
- Presented data from the Polish cohort of the CESAR study.
- Observed values were comparable to those reported by other international researchers.
- The study provides a substantial dataset for Polish children.
Conclusions:
- The study contributes valuable immunobiomarker data for Polish children.
- Findings support the similarity of immune parameters across different populations.
- Emphasizes the necessity for a unified, extensive database for healthy children's immunobiomarkers across age groups.
Abstract:
Determination of lymphocyte subpopulation values and immunoglobulin concentrations is an important tool in the assessment of immunologic system. The only way to establish their reference values in pediatrics is to perform research on large populations of healthy children from different age ranges in various areas of the world. Such research was conducted within the framework of the Central European Study of Air pollution and Respiratory Health (CESAR). It involved examination of children 9-11 years old from six countries in Central-Eastern Europe. We present the results of the Polish section of CESAR and compare them to the data provided by different authors from all over the world. Our data are relatively numerous: we examined 80 children recruited from primary schools in two Polish cities, Swietochlowice and Pszczyna. The values are similar to those obtained by other researchers. There is a need to establish an extensive and uniform data base of immunobiomarkers for healthy children in different age groups.
