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Published on: June 26, 2013
Inhibition of long-term potentiation by NMDA-mediated nitric oxide release
Y Izumi1, D B Clifford, C F Zorumski
1Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110.
Abstract:
Activation of N-methyl-D-aspartate (NMDA) receptors before tetanic stimulation blocks long-term potentiation (LTP) in the CA1 region of the hippocampus. This NMDA-mediated inhibition of LTP can be reversed by the nitric oxide (NO) inhibitors L-NG-monomethyl-arginine or hemoglobin and mimicked by sodium nitroprusside. These results indicate that the timing of NO release relative to high-frequency activation of CA1 synapses may be an important determinant of LTP generation and suggest that NO may play a positive or negative modulatory role in LTP depending on prior events at the tetanized synapse and the ambient concentration of excitatory amino acids.
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