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Choroid plexus carcinoma in an infant
W M Muhaizan1, A A Zurin, M A Aishah
1Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, Bandar Tun Razak, Cheras, 56000 Kuala Lumpur.
Insights
Choroid plexus carcinoma, a rare brain tumor in infants, has a poor prognosis. This case highlights a fatal outcome despite surgical tumor removal in a seven-month-old boy.
Area of Science:
- Pediatric Oncology
- Neuro-oncology
- Pediatric Neurosurgery
Background:
- Choroid plexus carcinoma is a rare and aggressive intracranial neoplasm predominantly affecting infants and young children.
- This tumor typically arises within the lateral ventricles, presenting a significant challenge due to its poor prognosis.
Observation:
- A seven-month-old infant presented with symptoms of increased intracranial pressure and seizures.
- Brain CT imaging revealed a large intraventricular mass with calcifications and associated hydrocephalus.
Findings:
- Complete macroscopic resection of the tumor was achieved.
- Histopathological diagnosis confirmed choroid plexus carcinoma.
- Despite surgical intervention, the patient unfortunately succumbed to the disease 11 days post-operatively.
Implications:
- This case underscores the critical need for improved therapeutic strategies for pediatric choroid plexus carcinoma.
- Further research into the histopathology and molecular underpinnings of this rare neoplasm is warranted.
- Early diagnosis and aggressive management are crucial, yet outcomes remain challenging.
Abstract:
Choroid plexus carcinoma is a rare intracranial neoplasm, affecting mainly very young children. The commonest site is within the lateral ventricles and the prognosis is very poor. We report a seven month old baby boy who presented with raised intracranial pressure and seizures. Brain CT scan showed large intraventricular mass with calcification and hydrocephalus. Total macroscopic resection of the tumour was performed and diagnosis of choroid plexus carcinoma was made. However, the patient died 11 days after the tumour excision. The histopathology of this rare childhood neoplasm is discussed.
