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Published on: April 22, 2019
[The correlation between neck lymphy node metastasis and matrixmetalloproteinase-2 expression at the invasive tumor
Lai-kui Liu1, Yi-ning Li, Hong-bing Jiang
1Dept. of Oral Pathology, West China College of Stomatology, Sichuan University, Chengdu 610041, China.
Objective:
To explore the correlation between neck lymph node metastasis and matrix metalloproteinase-2 expression at the invasive tumor front of oral squamous cell carcinomas(OSCC).
Methods:
Immunohistochemistry LsAB technique was used to observe the expression of MMP-2 at the invasive tumor front and center of OSCC, and the correlation between the expression of MMP-2 in OSCC and neck lymph node metastasis were respectively analyzed by statistics.
Results:
The results demonstrated that MMP-2 existed in all 71 cases, which the expression of MMP-2 at the OSCC front was more significant than that of MMP-2 at the OSCC center (P < 0.01), and related to neck lymph node metastasis (P < 0.05).
Conclusion:
The expression of MMP-2 at the OSCC front could be considered as an index of judging the present of neck lymph node metastasis of OSCC.
