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Published on: October 19, 2014
Localised extranodal lymphoma of the head and neck: the Sheffield Lymphoma Group experience (1971-2000)
S Hart1, J M Horsman, C R Radstone
1YCR Academic Unit of Clinical Oncology, Weston Park Hospital, Sheffield, UK.
Aims:
Over the 30-year period from 1971-2000, 3750 cases of lymphoma were referred to the Sheffield Lymphoma Group for investigation and treatment. Of these, 580 were extranodal presentations and, of these, 190 (33%) were localised to the head and neck region. The aim of this lymphoma database review was to evaluate the patient characteristics and survival rates for these patients.
Materials And Methods:
The sample included 98 women and 92 men, with a median age at presentation of 65 years.
Results:
The most common site affected was tonsil (34%), followed by salivary glands (16%). Other common sites were the thyroid, orbit and nasopharynx. The most frequent presenting feature was a swelling or mass, with pain, dysphagia and nasal obstruction also comprising large groups. All cases were non-Hodgkin's lymphoma. Fifty-five cases were histological grade 1; 132 were grade 2. Diffuse large B cell was the most common histological subtype. The overall 5- and 10-year survival rates were 55% (95% CI 47-62) and 44%, (95% CI 36-53), respectively, with a median survival of 92 months (95% CI 56-128). Stage and grade were both found to influence survival.
Conclusion:
This data concords with and extends information available from previous studies. More detail is now required on specific head and neck sites.
