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Related Experiment Videos

Polymorphonuclear leucocyte function during pregnancy.

B Björksten, T Söderström, M G Damber

    Scandinavian Journal of Immunology
    |January 1, 1978
    PubMed
    Summary

    Polymorphonuclear leucocyte (PMN) function is altered during pregnancy, with reduced chemotaxis and phagocytosis. Pregnancy zone protein (PZP) levels correlate with these immune changes, suggesting a role in modulating maternal immune responses.

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    Area of Science:

    • Immunology
    • Reproductive Biology
    • Cellular Physiology

    Background:

    • Pregnancy involves significant physiological adaptations, including alterations in immune function to accommodate the fetus.
    • Polymorphonuclear leucocytes (PMNs), critical immune cells, play a role in host defense, and their function may be modulated during gestation.

    Purpose of the Study:

    • To investigate polymorphonuclear leucocyte (PMN) function in pregnant women.
    • To correlate PMN function with serum concentrations of pregnancy zone protein (PZP).
    • To assess the impact of pregnancy serum on mixed lymphocyte culture (MLC) reactivity.

    Main Methods:

    • Assessed neutrophil chemotaxis in pregnant women.
    • Measured serum levels of pregnancy zone protein (PZP).

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  • Evaluated mixed lymphocyte culture (MLC) reactivity.
  • Assessed PMN nitroblue tetrazolium reduction capacity and phagocytosis of Escherichia coli.
  • Measured neutrophil chemiluminescence during zymosan phagocytosis.

    • Main Results:

    • Neutrophil chemotaxis was significantly depressed in pregnant women (P < 0.05).
    • Pregnancy serum inhibited MLC reactivity (P < 0.01) and phagocytosis of Escherichia coli.
    • PMNs from pregnant women showed depressed nitroblue tetrazolium reduction but increased chemiluminescence during zymosan phagocytosis.

    Conclusions:

    • Pregnancy-associated alterations in PMN function include reduced chemotaxis and phagocytosis, potentially mediated by pregnancy serum.
    • Elevated pregnancy zone protein (PZP) levels are inversely correlated with PMN chemotaxis and MLC reactivity.
    • Increased oxidative metabolism in PMNs from pregnant women may represent a compensatory mechanism.