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Related Experiment Videos

S100 proteins in the epidermis.

Richard L Eckert1, Ann-Marie Broome, Monica Ruse

  • 1Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA. rle2@po.cwru.edu

The Journal of Investigative Dermatology
|June 12, 2004
PubMed
Summary

S100 proteins are a family of calcium-binding proteins involved in epidermal cell function. Their altered expression is linked to skin diseases like psoriasis and cancer.

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Dermatology

Background:

  • S100 proteins are a family of 21 low molecular weight (9-13 kDa) proteins.
  • They possess two calcium-binding EF-hand motifs and are encoded by genes in the epidermal differentiation complex on human chromosome 1q21.
  • Thirteen S100 proteins are expressed in normal and diseased epidermis.

Purpose of the Study:

  • To investigate the role of S100 proteins in epidermal biology and disease.
  • To understand the function of S100 proteins as mediators of calcium-associated signal transduction.
  • To explore the involvement of S100 proteins in the pathogenesis of various epidermal conditions.

Main Methods:

  • Characterization of S100 protein family structure and calcium-binding properties.

Related Experiment Videos

  • Analysis of S100 protein gene localization and expression patterns in the epidermis.
  • Investigation of S100 protein dimerization and interaction with target proteins.

    • Main Results:

    • S100 proteins form homo- and heterodimers and regulate cell function upon calcium binding.
    • They undergo changes in subcellular distribution in response to stimuli and act as chemotactic agents.
    • Selected S100 proteins are significantly overexpressed in psoriasis, wound healing, skin cancer, and inflammation.

    Conclusions:

    • S100 proteins are key regulators of epidermal cell function and calcium signaling.
    • Their dysregulation contributes to the pathogenesis of several epidermal diseases.
    • S100 proteins represent potential therapeutic targets for skin conditions.