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Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
Published on: October 30, 2013
[Expression of IGF-I and IGF-IR in bladder cancer]
Qing-Xiang Xie1, Xia-Cong Lin, Min-Feng Zhang
1Department of Urology, The 175th Hospital of PLA, Zhangzhou, Fujian, PR China. xieqx@sohu.com
Background & Objective:
Insulin-like growth factors (IGF) is one of polypeptide growth factors that stimulate proliferation, survival, and differentiation in many cell types; their signal pathways implicate development and progression of many kinds of malignant tumor, while less study were undergone on the roles of IGF-I and IGF-IR in bladder cancer genesis. This study was designed to investigate the expression of IGF-I and IGF-IR and proliferation cell nuclear antigen (PCNA) in human normal and carcinomatous bladder cancer, and to explore the mechanism of IGF-I and IGF-IR in cellular proliferation and tumorigenesis of bladder cancer.
Methods:
Immunohistochemical methods were adopted to examine expression of IGF-I, IGF-IR, and PCNA in 88 cases with bladder cancer and 12 cases with normal bladder tissues. The relationship of expression of IGF-I and IGF-IR with various clinicopathological parameters and PCNA were analyzed.
Results:
The protein expression rates of IGF-I and IGF-IR in bladder cancer were 73.9% and 59.1%, significantly higher than 33.3% and 16.7% in normal tissues, respectively(P< 0.05). Both two protein expression were association with PCNA indexes in bladder cancer (P< 0.05). There were close relationship among IGF-I expression and tumor recurrence (P< 0.05), IGF-IR and tumor grade, stage and recurrence (P< 0.05).
Conclusion:
Abnormality of IGF-I-IGF-IR autocrine loop play an important role in development and progression of bladder cancer by promoting abnormal cellular proliferation. IGF-IR may be a marker for evaluating tumor biological behaviors.
Insights
Insulin-like growth factor-I (IGF-I) and its receptor (IGF-IR) are highly expressed in bladder cancer, correlating with increased cell proliferation and tumor progression. IGF-IR may serve as a biomarker for bladder cancer
Area of Science:
- Oncology
- Molecular Biology
- Cell Biology
Context:
- Insulin-like growth factors (IGF) are crucial signaling molecules involved in cell proliferation, survival, and differentiation.
- Their aberrant signaling pathways are implicated in the development and progression of various malignant tumors.
- The specific roles of IGF-I and its receptor (IGF-IR) in bladder cancer genesis remain less understood.
Purpose:
- To investigate the expression levels of IGF-I, IGF-IR, and proliferation cell nuclear antigen (PCNA) in human normal and cancerous bladder tissues.
- To explore the mechanistic role of IGF-I and IGF-IR in the cellular proliferation and tumorigenesis of bladder cancer.
- To analyze the correlation between IGF-I and IGF-IR expression and clinicopathological parameters, including tumor recurrence, grade, and stage.
Summary:
- Immunohistochemical analysis of 88 bladder cancer and 12 normal bladder tissues revealed significantly higher protein expression rates of IGF-I (73.9%) and IGF-IR (59.1%) in tumors compared to normal tissues (33.3% and 16.7%, respectively).
- Both IGF-I and IGF-IR expression were positively associated with PCNA indexes, indicating increased cellular proliferation.
- IGF-I expression correlated with tumor recurrence, while IGF-IR expression was linked to tumor grade, stage, and recurrence.
Impact:
- The findings suggest that an abnormal IGF-I-IGF-IR autocrine loop significantly contributes to bladder cancer development and progression by promoting uncontrolled cellular proliferation.
- IGF-IR emerges as a potential biomarker for evaluating tumor biological behaviors and predicting patient outcomes in bladder cancer.
- This research provides insights into the molecular mechanisms underlying bladder cancer and highlights potential therapeutic targets.
