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Updated: Aug 14, 2026
Laser-capture Microdissection of Human Prostatic Epithelium for RNA Analysis
Published on: November 26, 2015
[Expression and its significance of b-FGF in human benign prostatic hyperplasia and prostatic carcinoma tissues]
Fu-li Wang1, He Wang, Wei-jun Qin
1Department of Urology, Fourth Military Medical University, Xi'an 710032, China. wangfuli98@163.com
Aim:
To investigate the clinical significance of basic fibroblast growth factor (b-FGF) in human benign prostatic hyperplasia (BPH) and prostatic carcinoma (Pca).
Methods:
b-FGF expressions were examined by RNA dot blot hybridization and immunohistochemical staining in prostate tissues from 40 normal cases (NP), 38 BPH and 36 Pca.
Results:
The expressions of b-FGF in BPH and Pca tissues were significantly higher than those in normal prostate tissues (P < 0.01). There was no significant correlation between the increased expression of b-FGF and the graduation of BPH, pathologic grading as well as clinical stages of Pca.
Conclusion:
b-FGF may be secreted from BPH and Pca tissues themselves, which is closely involved in the genesis and development of BPH and Pca.
