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Epidemiology of arterial hypertension in renal transplant patients: changes over the last decade

Josep M Campistol1, Rafael Romero, Javier Paul

  • 1Renal Transplant Unit, Hospital Clinic, University of Barcelona, 170, Villarroel, 08036, Barcelona, Spain. jmcampis@clinic.ub.es

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
|June 12, 2004
PubMed

Insights

Arterial hypertension is common after renal transplantation, but control has improved. Newer treatments like tacrolimus and increased use of ACE inhibitors/ATII blockers show better outcomes.

Area of Science:

  • Nephrology
  • Cardiology
  • Transplantation Medicine

Background:

  • Arterial hypertension is a prevalent issue in renal transplant recipients.
  • It significantly impacts graft and patient survival rates.
  • Effective management is crucial for long-term outcomes.

Purpose of the Study:

  • To analyze trends in arterial hypertension prevalence and management post-renal transplantation.
  • To identify factors associated with hypertension development.
  • To evaluate the impact of different immunosuppressive therapies on hypertension.

Main Methods:

  • Retrospective analysis of 3365 adult renal transplant recipients from 1990, 1994, and 1998.
  • Hypertension defined as SBP ≥140 mmHg, DBP ≥90 mmHg, or antihypertensive drug use.
  • Recorded use of ACE inhibitors or ATII receptor blockers and immunosuppressive agents.

Main Results:

  • Hypertension prevalence increased over time, but blood pressure levels were lower in 1998.
  • Factors associated with hypertension included male gender, younger donor age, cyclosporine use, and higher creatinine.
  • Tacrolimus use was associated with lower hypertension prevalence and severity compared to cyclosporine.
  • Use of ACE inhibitors/ATII receptor blockers increased significantly.

Conclusions:

  • Arterial hypertension remains a significant challenge in renal transplantation.
  • Recent management strategies show improved control, with satisfactory intensity.
  • Increased utilization of ACE inhibitors and ATII receptor blockers is noted.
Abstract

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